Publications related to TINTIN research projects

Smith, J., Davey, G., Polom, K., Roviello, F. and Bones, J. (2018) Mining the acidic serum proteome utilizing off-gel isoelectric focusing and label free quantitative liquid chromatography mass spectrometry. J. Chromatogr. A. [DOI: 10.1016/j.chroma.2018.06.044]

Both, P., Riese, M., Gray, C.J., Huang, K., Pallister, E.G., Kosov, I., Conway, L.P., Voglmeir, J. and Flitsch, S.L. (2018) Applications of a highly α2,6-selective pseudosialidase. Glycobiology 28, 261–268. [DOI: 10.1093/glycob/cwy016]

Djikic, T., Martí, A.D., Y., Spyrakis, F., Lau, T., Benedetti, P., Davey, G., Schloss, P. and Yelekci, K. (2018) Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities. J. Biomol. Struct. Dyn. 0, 1–16. [DOI: 10.1080/07391102.2018.1426044]

Martí, Y., Nürnberg, E., Horschitz, S., Hafner, M., Schloss, P., Meyer-Lindenberg, A. and Lau, T. (2017) Refinement of a neuronal differentiation protocol predominantly yields human iPS cell-derived dopaminergic neurons for the investigation of neurodegenerative pathomechanisms in vitro. J. Cell. Biotechnol. 3, 61–80. [DOI: 10.3233/JCB-179007]

Lopez-Fabuel, I., Martin-Martin, L., Resch-Beusher, M., Azkona, G., Sanchez-Pernaute, R. and Bolaños, J.P. (2017) Mitochondrial respiratory chain disorganization in Parkinson’s disease-relevant PINK1 and DJ1 mutants. Neurochem. Int. 109, 101–105. [DOI: 10.1016/j.neuint.2017.03.023]

Fuente, C., Burke, D.G., Eaton, S. and Heales, S.J.R. (2017) Inhibition of neuronal mitochondrial complex I or lysosomal glucocerebrosidase is associated with increased dopamine and serotonin turnover. Neurochem. Int. 109, 94–100. [DOI: 10.1016/j.neuint.2017.02.013]

Martí, A.D., Y., Matthaeus, F., Lau, T. and Schloss, P. (2017) Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol. Cell. Neurosci. 83, 37–45. [DOI: 10.1016/j.mcn.2017.06.009]

Barros, L.F., Bolaños, J.P., Bonvento, G., Bouzier-Sore A,-K., Brown, A., Hirrlinger, J., Kasparov, S., Kirchhoff, F., Murphy, A.N., Pellerin, L., Robinson, M.B. and Weber, B. (2017) Current technical approaches to brain energy metabolism. Glia 66, 1138–1159. [DOI: 10.1002/glia.23248]

Lopez-Fabuel, I., Resch-Beusher, M., Carabias-Carrasco, M., Almeida, A. and Bolaños, J.P. (2017) Mitochondrial complex I activity is conditioned by supercomplex I-III2-IV assembly in brain cells: relevance for Parkinson’s disease. Neurochem. Res. 42, 1676–1682. [DOI: 10.1007/s11064-017-2191-2]

Mittermayr, S., Albrecht, S., Váadi, C., Millán-Martín, S. and Bones, J. Stable isotope quantitative N-glycan analysis by liquid separation techniques and mass spectrometry. I n: Espina V. et al. (Eds), Molecular Profiling, Methods Mol. Biol., vol. 1606, 2017, pp. 353–366. [DOI: 10.1007/978-1-4939-6990-6_23]

Munster, J.M., Thomas, B., Riese, M., Davis, A.L., Gray, C.J., Archer, D.B. and Flitsch, S.L. (2017) Application of carbohydrate arrays coupled with mass spectrometry to detect activity of plant-polysaccharide degradative enzymes from the fungus Aspergillus niger. Sci. Rep. 7, 43117. [DOI: 10.1038/srep43117]

Smith, J., Mittermayr, S., Váradi, C. and Bones, J. (2017) Quantitative glycomics using liquid phase separations coupled to mass spectrometry. Analyst 142, 700–720. [DOI: 10.1039/c6an02715f]

Fernandez, E. and Bolaños, J.P. (2016) α-Ketoglutarate dehydrogenase complex moonlighting: ROS signalling added to the list. J. Neurochem. 139, 689–690. [DOI: 10.1111/jnc.13862]

Váradi, C., Mittermayr, S., Millán-Martín, S. and Bones, J. (2016) Quantitative twoplex glycan analysis using 12C6 and 13C6 stable isotope 2-aminobenzoic acid labelling and capillary electrophoresis mass spectrometry. Anal. Bioanal. Chem. 408, 8691–8700. [DOI: 10.1007/s00216-016-9935-8]

Lopez-Fabuel, I., Douce, J.L., Logan, A., James, A.M., Bonvento, G., Murphy, M.P., Almeida, A. and Bolaños, J.P. (2016) Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes. Proc. Natl. Acad. Sci. U.S.A. 113, 13063–13068. [DOI: 10.1073/pnas.1613701113]

Tudela, M.V.-P., Maestre, C., Delgado-Esteban M., A.D., Bolaños, J.P. and Almeida, A. (2015) Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons. Sci. Rep. 5:18180. [DOI: 10.1038/srep18180]

Requejo-Aguilar, R. and Bolaños, J.P. (2016) Mitochondrial control of cell bioenergetics in Parkinson’s disease. Free Radical Bio. Med. 100, 123–137. [DOI: 10.1016/j.freeradbiomed.2016.04.012]

McDonald, A.G., Hayes, J.M. and Davey, G.P. (2016) Metabolic flux control in glycosylation. Curr. Opin. Struc. Biol. 40, 97–103. [DOI: 10.1016/j.sbi.2016.08.007]

Bolaños, J.P. (2016) Bioenergetics and redox adaptations of astrocytes to neuronal activity. J. Neurochem. 139, 115–125. [DOI: 10.1111/jnc.13486]  

McDonald, A.G., Tipton, K.F. and Davey, G.P. (2016) A knowledge-based system for display and prediction of O-glycosylation network behaviour in response to enzyme knockouts. PLoS Comput. Biol. 12, e1004844. [DOI: 10.1371/journal.pcbi.1004844]

Hawkins, K.E., Joy, S., Delhove, J.M.K.M., Kotiadis, V.N., Fernandez, E., Fitzpatrick, L.M., Whiteford, J.R., King, P.J., Bolanos, J.P., Duchen, M.R., Waddington, S.N. and McKay, T.R. (2016) NRF2 orchestrates the metabolic shift during induced pluripotent stem cell reprogramming. Cell Rep. 14, 1883–1891. [DOI: 10.1016/j.celrep.2016.02.003]

Hayes, J., Wormald, M., Rudd, P. and Davey, G. (2016) Fc γ receptors: glycobiology and therapeutic prospects. J. Inflamm. Res. Volume 9, 209–219. [DOI: 10.2147/JIR.S121233]

Santofimia-Castaño, P., Ruy, D.C., Garcia-Sanchez, L., Jimenez-Blasco, D., Fernandez-Bermejo, M., Bolaños, J.P., Salido, G.M. and Gonzalez, A. (2015) Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells. Free Radical Bio. Med. 87, 226–236. [DOI: 10.1016/j.freeradbiomed.2015.06.033]

Bouzier-Sore, A.-K. and Bolaños, J.P. (2015) Uncertainties in pentose-phosphate pathway flux assessment underestimate its contribution to neuronal glucose consumption: relevance for neurodegeneration and aging. Front. Aging Neurosci. 7:89. [DOI: 10.3389/fnagi.2015.00089]

Dunn, L., Fairfield, V., Daham, S., Bolaños, J. and Heales, S. (2014) Pentose-phosphate pathway disruption in the pathogenesis of Parkinson’s disease. Transl. Neurosci. 5, 179–184. [DOI: 10.2478/s13380-014-0221-y]

Nikolic, K., Mavridis, L., Djikic T., Vucicevic, J., Agbaba, D., Yelekci, K. and Mitchell, J.B.O. (2016) Drug design for CNS diseases: polypharmacological profiling of compounds using cheminformatic, 3D-QSAR and virtual screening methodologies. Front. Neurosci. 10 00265. [DOI: 10.3389/fnins.2016.00265]

Begüm Evranos-Aksö, İpek Baysal, Samiye Yabanoğlu-Çiftçi, Teodora Djikic, Kemal Yelekçi, Gülberk Uçar and Rahmiye Ertan (2015) Synthesis and screening of human monoamine oxidase-A: inhibitor effect of new 2-pyrazoline and hydrazone derivatives. Arch. Pharm. Chem. Life Sci., 348, 743–756.
[DOI: 10.1002/ardp.201500212]

Horschitz, S., Matthaus, F., Groß, A., Rosner, J., Galach, M., Greffrath, W., Treede, R.D., Utikal, J., Schloss, P. and Meyer-Lindenberg, A. Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons. Stem Cell Res. 15 (2015) 30–41.
[PMID: 26001168]

News

  • Discover Research Dublin night (September 25th 2015) An opportunity to share scientific research with the general public.
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  • Advanced Microscopy and Super Resolution (Andor) 07-09/05/15, Trinity College, Dublin: Lectures on the fundamentals of fluorescence imaging including a breakdown of different types of fluorescent probes including dyes, antibodies and fluorescent proteins were given.
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© 2018 TINTIN - A Marie Curie Initial Training Network Programme funded under Grant Agreement No. 608381