TINTIN is a pan-European, multi-disciplinary project aimed at training 12 PhD students in neuroscience research, with an emphasis on the basis of neurodegeneration,
neurotherapeutics development and neurorepair. The project is funded under the EU Framework 7. PhD candidates
are currently involved in advanced research training projects on metabolism and autophagy in neurons, induced pluripotent stem cells and neurorepair systems. Parallel research
projects involves computational modelling of metabolism in the dopamine neuron and the in silico design of novel therapeutics that are selectively transported into the
dopamine neuron. This fundamental training and research will be merged with new cutting edge glycan based biomarker technologies, drug simulation and
computational/mathematical models of dopaminergic neurons. Each PhD candidate will be seconded for 3–5 month period to a European industrial partner appropriate to their
research project, to obtain training in leading-edge technologies. Candidates are also being provided with training in aspects of project management and commercial innovation.
The scientific and technological objectives of TINTIN will use interdisciplinary approaches:
- To discover how autophagy in the dopamine neuron is related to lysosomal and mitochondrial
- To discover how novel genetic mutations in glycolipid and ganglioside metabolism relate to
dopamine neuron degeneration.
- To utilize pluripotent stem cell technologies for studying dopaminergic neurodegeneration.
- To utilize computational and molecular design techniques to identify novel aspects of the
neurodegenerative processes that may be selected as therapeutic targets.
- To identify and validate novel glycan-based biomarkers for use in clinical trials.